Sir William FitzWilliam (1506 – 3 October 1559), of Windsor, Berkshire, was an Irish courtier and Member of Parliament in England. He was Chief Gentleman of the Privy Chamber to Edward VI of England; Deputy Chancellor of Ireland; Lieutenant of Windsor Castle; Keeper of Windsor Great Park and Lord Lieutenant of Berkshire.
He was the second son of Thomas Fitzwilliam (1465-1517), of Baggotrath Castle, Co. Dublin; Sheriff of Dublin City. His mother, Eleanor, was the daughter of Sir John Dowdall, of Newtown, Co. Kildare, and co-heir to her mother, Margaret, daughter of Sir Jenico d’Artois of Ardglass Castle and Strangford Castle, Co. Down. His mother was the step-daughter of Rowland FitzEustace, 1st Baron Portlester, father-in-law of Gearóid Mór FitzGerald, 8th Earl of Kildare.
In 1532, he was Clerk of the Hanaper. In 1536, he and his brother, Richard, came to England. His brother entered into the service of their cousin, Gerald FitzGerald, 9th Earl of Kildare, and became Gentleman of the Bedchamber to Henry VIII. William entered the service of his kinsman William FitzWilliam, 1st Earl of Southampton. He was a Member (MP) of the Parliament of England for Guildford in 1539 and 1542, for New Shoreham in 1547, and for Berkshire in March 1553 and 1559. By 1544, he was Chief Gentleman of the Privy Chamber to Prince Edward. He was Gentleman of the Privy Chamber from 1547 to 1553. Knighted in 1551/2 by King Edward VI, he was made Lieutenant of Windsor Castle and Keeper of Windsor Great Park, through the influence of John Dudley, 1st Duke of Northumberland. He was Deputy Chancellor of Ireland from 1554 to 1556. In 1559, the year of his death, he was made Lord Lieutenant of Berkshire. He was spoken of by Elizabeth I as a person who stood high in her esteem.