William E. Kerstetter (1913–1996) was president of DePauw University and earlier of Simpson College.
Kerstetter had a bachelor's degree from Dickinson College. He had a Ph.D. from Boston University. He was an ordained Methodist minister who spent most of his career in academia. Before become president of Simpson College he was a professor of philosophy at Hamline University.
From 1953-1963 Kerstetter was president of Simpson College. Under his leadership the college grew and it initiated an exchange program with Oxford University.
Kerstetter became president of DePauw in 1963. He immediately began a major fundraising campaign. The main buildings constructed at DePauw during Kerstetter's tenure were the women's upper class dormitory known as Hogate Hall and the science building which in 1982 was named the Julian Science and Mathematics Center after DePauw alumni Percy L. Julian. Also during Kerstetter's tenure the connection between DePauw and the Methodist Church was lessened.
In 1975 Kerstetter resigned as president of DePauw but was appointed Chancellor of the University with responsibility almost exclusively in the matter of fundraising. Kerstetter retired from the latter position in 1978.