William Cuninghame of Lainshaw (c.1775–1849) was a Scottish landowner, known as a writer on biblical prophecy. He dated the beginning of the reign of Antichrist to 533 A.D., to coincide with a claimed date at which Justinian I gave universal rule to the Papacy, by subtracting 1260 years from the date after the French Revolution at which it was seen to turn against the Roman Catholic Church.
He was the son of William Cunninghame (died 1804), a prosperous tobacco merchant of Glasgow, who in 1779 bought the Lainshaw estate, Stewarton, Ayrshire. Educated at the University of Utrecht, he joined the Bengal civil service of the East India Company. While in India he was influenced by William Carey the Baptist missionary. He returned to Scotland in 1804.
Cuninghame was one of a group of British biblical interpreters of the early 19th century, including also Edward Bickersteth, Thomas Rawson Birks, Joshua William Brooks, and Edward Bishop Elliott, who combined premillennialism with a more traditional historicist reading of prophecy. The movement came to include Hugh M'Neile, Edward Irving and John Nelson Darby.