William Brereton, 1st Baron Brereton (1550 – 1 October 1631) was an English politician who sat in the House of Commons at various times between 1597 and 1622. He was created a peer in the Peerage of Ireland in 1624 as Baron Brereton.
Brereton was the son of Sir William Brereton of Brereton, Cheshire and was baptised on 6 February 1550. He was about nine when his father died in 1559 and he succeeded to the extensive family estates. He was educated at Oxford University and was awarded BA in 1568. He was admitted at Lincoln's Inn in 1569. From 1573 he was JP for Cheshire and was High Sheriff of Cheshire from 1581 to 1582. In 1586 he built a mansion at Brereton which was similar to Rocksavage, the house of his father-in-law Sir John Savage. He was knighted in 1588. He was commissioner for musters in 1595 and in 1596.
In 1597, Brereton was elected Member of Parliament for Cheshire. He was elected MP for Cheshire again in 1614 and in 1621. He had an estate near Old Leighlin, for which he and his heirs were absentee landlords. He was created Baron Brereton of Leighlin in the County of Carlow on 11 May 1624. Brereton died at the age of about 80 and was buried at Brereton.
Brereton married Margaret Savage, daughter of Sir John Savage of Rocksavage, Cheshire, and Lady Elizabeth Manners (d. 1570), daughter of Thomas Manners, 1st Earl of Rutland. They had four sons and four daughters. Most of them died young two who survived to marry were: