Sir William Brandford Griffith, K.C.M.G. (11 August 1824, Barbados – 1897, Barbados) was a British administrative official, Governor of the Gold Coast from 1880 to 1881 and again from 1885 to 1895.
Brandford Griffith was lieutenant-governor in the Gold Coast, and acting governor from 1 December 1880 until 4 March 1881, when Sir Samuel Rowe was appointed governor. On Governor Young's death, he became Governor of the colony for a decade, from 24 April 1885 until retirement on 7 April 1895.
He is buried at St. Michael’s Cathedral, Bridgetown, Barbados.
His son, Sir William Brandford Griffith, was Chief Justice of the Gold Coast from 1895 to 1911.