William Barlow (October 26, 1822 – June 18, 1904) was an early Oregon pioneer and founder of Barlow, Oregon, United States.
Barlow arrived in Oregon as a young man in 1845. He purchased land and founded the town of Canemah, now part of Oregon City, Oregon.
In 1852 he married widow Mrs. Martha Ann Allen; they had three children: Mary, Virginia and Cassius.
Sometime after 1848, Barlow purchased a 640-acre (260 ha) land claim from his father Sam Barlow for $6,000. In 1891, he founded the town of Barlow on that land. His residence, now known as the Barlow House, still stands near Barlow.