William Anthony Hughes (September 23, 1921 - February 7, 2013) was an American prelate of the Roman Catholic Church. He served as Bishop of Covington from 1979 to 1995.
William Hughes was born in Youngstown, Ohio, to James and Anna (née Philbin) Hughes, who were Irish immigrants. After attending Ursuline High School in Youngstown, he studied at St. Charles College in Catonsville, Maryland, from where he graduated summa cum laude. He returned to Ohio and completed his theological studies at St. Mary Seminary in Cleveland. He was ordained to the priesthood by Bishop James A. McFadden on April 6, 1946.
He then served as a curate at St. Charles Church in Boardman and St. Joseph Church in Massillon. In 1956 he earned a Master's degree in Education from the University of Notre Dame. Hughes was the founding principal of Cardinal Mooney High School from 1956 until 1965, when he became superintendent of Catholic schools and vicar for education in the Diocese of Youngstown. He was raised to the rank of Monsignor by Pope John XXIII in 1961.