Whitworth Female College was a Methodist women's college in Brookhaven, Mississippi, founded in 1858 by Milton Whitworth.
The college was founded in 1858 by Milton J. Whitworth, opened in 1859, and disestablished in 1984. It was associated with the Mississippi Methodist Conference until 1938.
During the Civil War the college was used as a Confederate hospital and managed to reopen after the war's end.
In August 1878, local freemasons laid the cornerstone for a new brick building at the college, into which a time capsule was placed. Both U.S. Senator from Mississippi Lucius Quintus Cincinnatus Lamar II and Jefferson Davis were expected to attend the ceremony but were "unavoidably absent."
In 1925 the College was first accredited by the Southern Association of Colleges and Schools. In 1928 the College began operation as a two-year institution associated with Millsaps College in Jackson, Mississippi. In 1938, because of financial difficulties, the board of trustees of the College voted to cease operations and merge the school with Millsaps College. The city of Brookhaven bought the campus and leased it out to various short-lived colleges between 1941 and 1984, when all educational operations at the location ceased.
In 2003 the state of Mississippi opened the Mississippi School of the Arts on the grounds of the former college.
During his term as Governor of Mississippi (1904-1908), white supremacist politician James Kimble Vardaman, known as the "Great White Chief," spoke at the college and was presented with a bouquet and the following poem: