The Second Melbourne ministry was formed in the United Kingdom of Great Britain and Ireland by the Viscount Melbourne in 1835.
Lord Melbourne's second government came to power after Sir Robert Peel's minority government resigned in 1835. Lord Palmerston returned as Foreign Secretary while Lord John Russell held his first major office as Home Secretary.
In 1837 Queen Victoria succeeded to the throne, and as was usual for a queen regnant, the Royal Household was appointed by the Prime Minister. The young Queen was so attached to her Whig ladies of the bedchamber that after Melbourne's resignation in 1839, she refused to let Sir Robert Peel replace them with Conservative ladies. This was known as the Bedchamber Crisis, and led to Peel's refusal to form a government. Melbourne therefore resumed, and continued in office until the Conservatives finally won a House of Commons majority in the General Election of 1841. He was succeeded by Sir Robert Peel's second government.
The 1841 vote of no confidence against the government of Viscount Melbourne was a vote of no confidence in the government of William Lamb, 2nd Viscount Melbourne which occurred on the 7 June 1841. Melbourne lost the vote by only one vote and dissolved Parliament leading to an election in July 1841.