"When Love Takes Over" is a song by French DJ-music producer David Guetta with vocals by Kelly Rowland from his fourth studio album, One Love. It was released as the lead single from the album on 21 April 2009 by Virgin Records (EMI France). The song was conceived when Guetta played the instrumental version during one of his DJ sets in summer 2008; American recording artist Kelly Rowland, who fell in love with the track, convinced Guetta to allow her to take it so that she could write and record vocals for it. It was co-written by Nervo.

According to Rowland, the song inspired her to pursue a more dance-oriented sound for her album Here I Am (2011), while Guetta noted "When Love Takes Over" for providing the framework for his future musical explorations and inspiring him to experiment with more urban sounds. Guetta and Frédéric Riesterer produced the song with piano riffs and a melodic backing track. Veronica Ferraro mixed the song, focussing primarily on giving Rowland's vocals a magical and inspiring tone. Critics would later state that Rowland's vocals on "When Love Take Over" helped to establish herself as a solo vocalist. The song's lyrics carry a message of the euphoria one feels when in love with a significant other, while the production bears some similarities to Coldplay's 2002 hit single, "Clocks", particularly the opening riff.

"When Love Takes Over" has been praised by many critics. Most noted the addition of Rowland's powerful and emotionally charged vocals which made the single the most memorable song from One Love. The production was praised for its lush production and euphoric sentiments. It achieved worldwide success by topping the charts in ten countries, including in the United Kingdom, Republic of Ireland, Italy and Switzerland. At the time of release, it became Guetta's highest charting single on the U.S. Billboard Hot 100 and Rowland's second number one single in the United Kingdom. "When Love Takes Over" ranked at number one on Billboard's Best of 2009 Dance Club Songs chart. In 2013, Billboard named "When Love Takes Over" its number one dance-pop collaboration of all time, in addition to noting the lasting cultural impact that the collaboration would have on dance music and its indication of the emerging electronic dance music trend in America at its time of release.

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