Wayne Grigsby (born 1947) is a Canadian screenwriter and producer, mainly for television.
Grigsby, who hails from Calgary, started in journalism which was primarily arts and entertainment. His goal had always intended to write fiction. He was able to get a script produced by Brian McKenna and Bernie Zukerman, which led to his becoming a screenwriter. Later he formed Big Motion Pictures Inc. with David MacLeod. He also tried American TV with a failed pilot starring Kelly McGillis.