The Wayne County School District is a public school district based in Waynesboro, Mississippi (USA). The district's boundaries parallel that of Wayne County.
There were a total of 3,896 students enrolled in the Wayne County School District during the 2006-2007 school year. The gender makeup of the district was 51% female and 49% male. The racial makeup of the district was 54.36% African American, 45.07% White, 0.23% Hispanic, 0.21% Asian, and 0.13% Native American. 65.5% of the district's students were eligible to receive free lunch.