"Wake Up" is a song recorded by American singer Hilary Duff for her first compilation album, Most Wanted (2005). It was co-written by Duff and the Dead Executives, who also produced the song. Along with the three other new recordings on Most Wanted, "Wake Up" was crafted with the intention of having a "totally different sound" from Duff's previous material. Although she thought of the work to be a new milestone in her career, she was at the same time nervous about her fans would react to the material. "Wake Up" was released as the lead single from Most Wanted on July 12, 2005.

Described by Duff as an '80s-influenced dance-pop song, "Wake Up" is lyrically about going out and having fun. The song was released digitally in the United Kingdom on October 24, 2005.

"Wake Up" received mixed reviews from critics. Some praised it for being "irresistible" and having a fun nature, while others criticized it for its "insipid" lyrics and noted that it sounds like "leftovers" from Duff's previous releases. The song achieved some commercial success, becoming a top-ten hit in Ireland, Norway, Spain and the United Kingdom. It reached the top forty in several other countries: Australia, the Netherlands, New Zealand, Switzerland and the United States. The song's accompanying music video features Duff leaving her house and attending various nightclubs and parties.

On May 20, 2005, MTV News reported that Duff would be releasing a new album in August, comprising previously released tracks and four new recordings. It was also announced that preceding the album's release, Duff would begin a 32-date summer concert tour in support of the album. The following month, in an interview with MTV News, Duff said that she had been working with brothers Joel and Benji Madden, of the American rock band Good Charlotte, and Jason Epperson (together known under the production name the Dead Executives) to write and produce new songs for the compilation. She said that " ... they're three of my favorite songs I've ever done. ... It was really fun being in the studio with them." Described by Duff as the first time when "all the responsibility was on [her]", she went into the recording studio without the guidance of her record label or management.

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