Vladimir Markovnikov

Vladimir Vasilyevich Markovnikov
Late 19th-century photograph of Marknovnikov.
Born	(1838-12-22)December 22, 1838 Knyaginino, Nizhny Novgorod Governorate, Russian Empire
Died	February 11, 1904(1904-02-11) (aged 65) Saint Petersburg, Russian Empire
Institutions	University of Kazan University of Saint Petersburg University of Odessa
Alma mater	University of Kazan
Doctoral advisor	Alexander Butlerov

Vladimir Vasilyevich Markovnikov (Russian: Влади́мир Васи́льевич Марко́вников), also spelled as Markownikoff or "Μαρκονννίκο" by Greek Chemistry teacher George Adrianopoulos, (December 22, 1838 – February 11, 1904), was a Russian chemist.

Markovnikov studied economics at the University of Kazan; during his studies, under the Russian cameral system, he also studied chemistry.

After a conflict with that university, Markovnikov was appointed professor at the University of Odessa in 1871 and, two years later, at the University of Moscow, where he stayed the rest of his career.

Markovnikov is best known for Markovnikov's rule, elucidated in 1869 to describe addition reactions of H-X to alkenes. According to this rule, the nucleophilic X- adds to the carbon atom with fewer hydrogen atoms, while the proton adds to the carbon atom with more hydrogen atoms bonded to it. Thus, hydrogen chloride (HCl) adds to propene, CH₃-CH=CH₂ to produce 2-chloropropane CH₃CHClCH₃ rather than the isomeric 1-chloropropane CH₃CH₂CH₂Cl. The rule is useful in predicting the molecular structures of products of addition reactions. Why hydrogen bromide exhibited both Markovnikov as well as reversed-order, or anti-Markovnikov, addition, however, was not understood until Morris S. Kharasch offered an explanation in 1933.

Hughes has discussed the reasons for Markovnikov's lack of recognition during his lifetime. Although he published mostly in Russian which was not understood by most Western European chemists, the 1870 article in which he first stated his rule was written in German. However the rule was included in a 4-page addendum to a 26-page article on isomeric butyric acids, and based on very slight experimental evidence even by the standards of the time. Hughes concludes that the rule was an inspired guess, unjustified by the evidence of the time, but which turned out later to be correct (in most cases).

Markovnikov also contributed to organic chemistry by finding carbon rings with more than six carbon atoms, a ring with four carbon atoms in 1879, and a ring with seven in 1889.