Vitalism is the belief that "living organisms are fundamentally different from non-living entities because they contain some non-physical element or are governed by different principles than are inanimate things". Where vitalism explicitly invokes a vital principle, that element is often referred to as the "vital spark", "energy" or "élan vital", which some equate with the soul. In the 18th and 19th century vitalism was discussed among biologists, in a discussion between those who felt that the known mechanics of physics would eventually explain the difference between life and non-life and vitalists who argued that life could not be reduced to a mechanistic process. Some vitalist biologists proposed testable hypotheses meant to show inadequacies with mechanistic explanations, but these experiments failed to provide support for vitalism. Biologists now consider vitalism to have been refuted by empirical evidence, and hence as belonging to the realm of religion rather than that of science.
Vitalism has a long history in medical philosophies: most traditional healing practices posited that disease results from some imbalance in vital forces.
The notion that bodily functions are due to a vitalistic principle existing in all living creatures has roots going back at least to ancient Egypt. In Greek philosophy, the Milesian school proposed natural explanations deduced from materialism and mechanism. However, by the time of Lucretius, this account was supplemented, (for example, by the unpredictable clinamen of Epicurus), and in stoic physics, the pneuma assumed the role of logos. Galen believed the lungs draw pneuma from the air, which the blood communicates throughout the body.