Vengeance (2006) was a professional wrestling pay-per-view (PPV) event produced by World Wrestling Entertainment (WWE), which took place on June 25, 2006, at the Charlotte Bobcats Arena in Charlotte, North Carolina. It was the sixth annual Vengeance event. Eight professional wrestling matches were featured on the event's card. The buildup to the matches and the scenarios that took place before, during, and after the event were planned by WWE's script writers. The event starred wrestlers from the Raw brand: a storyline expansion of the promotion where employees are assigned to a wrestling brand under the WWE banner.

The card featured eight televised matches, including two main events which resulted in Rob Van Dam defeating Edge to retain the WWE Championship and D-Generation X (DX) (Triple H and Shawn Michaels) defeating Spirit Squad (Kenny, Johnny, Mitch, Nicky, and Mikey) in a 5-on-2 Handicap match. One bout was featured on the undercard, in which John Cena defeated Sabu in an Extreme lumberjack match, which featured superstars from the Raw and ECW brands at ringside.