Vasicine
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IUPAC name
1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazolin-3-ol
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| Other names
Peganine
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| Identifiers | |
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3D model (JSmol)
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PubChem CID
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| Properties | |
| C11H12N2O | |
| Molar mass | 188.23 g·mol−1 |
| Melting point | 210 °C (410 °F; 483 K) |
| Solubility in acetone, alcohol, chloroform | Soluble |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| Infobox references | |
Vasicine (peganine) is a quinazoline alkaloid. It is the active compound of Justicia adhatoda, after which the chemical is named.
Vasicine has been compared to theophylline both in vitro and in vivo. It has also been studied in combination with the related alkaloid vasicinone. Both the alkaloids in combination (1:1) showed pronounced bronchodilatory activity in vivo and in vitro. Both alkaloids are also respiratory stimulants. Vasicine has a cardiac–depressant effect, while vasicinone is a weak cardiac stimulant; the effect can be normalized by combining the alkaloids. Vasicine is reported to have a uterine stimulant effect.
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Wikipedia