VEGF receptor
| fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | |
|---|---|
 |
|
| Identifiers | |
| Symbol | FLT1 |
| Alt. symbols | FLT |
| Entrez | 2321 |
| HUGO | 3763 |
| OMIM | 165070 |
| RefSeq | NM_002019 |
| UniProt | P17948 |
| Other data | |
| EC number | 2.7.1.112 |
| Locus | Chr. 13 q12 |
| kinase insert domain receptor (a type III receptor tyrosine kinase) | |
|---|---|
| Identifiers | |
| Symbol | KDR |
| Alt. symbols | FLK1, VEGFR, VEGFR2, CD309 |
| Entrez | 3791 |
| HUGO | 6307 |
| OMIM | 191306 |
| RefSeq | NM_002253 |
| UniProt | P35968 |
| Other data | |
| EC number | 2.7.1.112 |
| Locus | Chr. 4 q11-q12 |
| fms-related tyrosine kinase 4 | |
|---|---|
| Identifiers | |
| Symbol | FLT4 |
| Alt. symbols | VEGFR3, PCL |
| Entrez | 2324 |
| HUGO | 3767 |
| OMIM | 136352 |
| RefSeq | NM_002020 |
| UniProt | P35916 |
| Other data | |
| EC number | 2.7.1.112 |
| Locus | Chr. 5 q34-q35 |
VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Also, they may be membrane-bound (mbVEGFR) or soluble (sVEGFR), depending on alternative splicing.
Vascular endothelial growth factor (VEGF) is an important signaling protein involved in both vasculogenesis (the formation of the circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). As its name implies, VEGF activity is restricted mainly to cells of the vascular endothelium, although it does have effects on a limited number of other cell types (e.g. stimulation monocyte/macrophage migration). In vitro, VEGF has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF also enhances microvascular permeability and is sometimes referred to as vascular permeability factor.
All members of the VEGF family stimulate cellular responses by binding to tyrosine kinase receptors (the VEGFRs) on the cell surface, causing them to dimerize and become activated through transphosphorylation. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain.
VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF. The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 is to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). In fact, an alternatively spliced form of VEGFR-1 (sFlt1) is not a membrane bound protein but is secreted and functions primarily as a decoy. A third receptor has been discovered (VEGFR-3), however, VEGF-A is not a ligand for this receptor. VEGFR-3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D.
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Wikipedia