A constitutional referendum was held in Uruguay on 16 December 1951. The proposed amendments to the constitution were approved by 54% of voters.
The proposed changes to the constitution were presented to the General Assembly on 31 June 1951. The Chamber of Deputies approved it by a vote of 85 to 14 on 10 October, whilst the Senate approved it by a vote of 26 to 4 on 26 October.
The amendments would:
The collegiado system was reintroduced prior to the 1954 general elections.