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The 2010 United States Senate election in Pennsylvania took place on November 2, 2010, during the 2010 midterm elections. Incumbent Republican-turned-Democrat U.S. Senator Arlen Specter ran for reelection to a sixth term, but lost in the Democratic primary to Joe Sestak. Republican nominee Pat Toomey then won the seat.
Toomey had previously run for United States Senate in 2004, challenging Specter for the Republican nomination, but was narrowly defeated in the primary. Specter went on to be reelected to his fifth term, defeating the Democratic nominee, Congressman Joe Hoeffel. Toomey announced on April 15, 2009, that he would again seek the Republican nomination for U.S. Senate in the 2010 election.
The primary season was marked by Specter's decision in early 2009 to switch from the Republican Party to the Democratic Party, pitting him against Sestak in the Democratic primary. The contest, characterized by attacks between the two Democratic candidates, was one of the most-watched primary races of the 2010 election cycle. Sestak ultimately defeated Specter in the May 18 primary, garnering 53.9% of the vote, to Specter's 46.1%. Pat Toomey easily defeated challenger Peg Luksik for the Republican nomination. Toomey received 81.5% of the vote, to Luksik's 18.5%.