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County results
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The 2006 United States Senate election in Mississippi was held on November 7, 2006. Incumbent Republican U.S. Senator Trent Lott won re-election to a fourth term.
Lott ran for re-election without facing any opposition in his party's primary. While it had been speculated that Lott might retire after his home was destroyed in Hurricane Katrina, he instead chose to run for re-election. Fleming is an African American, which represents 37% of the state's population. However, no African American has ever been elected to statewide office. The last black U.S. Senator was Hiram Revels, who was appointed and took office in 1870. Fleming got little help from the DSCC, which only donated $15,000 to his campaign.