There are nine historic districts in Meridian, Mississippi. Each of these districts is listed on the National Register of Historic Places. One district, Meridian Downtown Historic District, is a combination of two older districts, Meridian Urban Center Historic District and Union Station Historic District. Many architectural styles are present in the districts, most from the late 19th century and early 20th century, including Queen Anne, Colonial Revival, Italianate, Art Deco, Late Victorian, and Bungalow.
East End Historic District is roughly bounded by 18th St on the north, 11th Ave on the east, 14th St on the south, and 17th Ave on the west. A semi-triangular shaped section extends from the southern edge roughly occupying the area between 16th and 14th Avenues. The 970-acre (3.9 km2) district was added to the National Register of Historic Places on August 21, 1987. The district's significance lies in its large collection of Queen Anne–style and Colonial Revival–style cottages built between 1890 and 1910 during Meridian's "Golden Age." Sixty percent of the buildings in the district are from this time period, representing Meridian's rapid eastward growth along the railroad lines after the American Civil War. This growth was made possible by the development of transportation, industrial, and commercial sectors of the city's economy.
Richard McLemore, one of the founders of the city, built his first cabin just outside the district and claimed much of the area in the district to be part of his cotton plantation. In 1839 he established a cemetery (now listed on the National Register of Historic Places as McLemore Cemetery), which is Meridian's earliest remaining historic site. In 1853 Lewis Ragsdale, another one of Meridian's founders, purchased much of McLemore's plantation and subdivided it, giving rise to the many residences in this district. Because of textile and planing businesses located along a streetcar line, 16th Ave became a major North-South route through the city and was the first street in the city to be paved.