UFC Fight Night: Henderson vs. dos Anjos (also known as UFC Fight Night 49) was a mixed martial arts event held on August 23, 2014 at the BOK Center in Tulsa, Oklahoma.

The event was headlined by Lightweight contenders Benson Henderson and Rafael dos Anjos.

The event is the second visit to Tulsa, Oklahoma, the first being UFC 4, nearly 20 years ago.

Jordan Mein was expected to face Thiago Alves at the event. However, Alves pulled out of the bout with an injury and was replaced by Brandon Thatch. Subsequently, Thatch also pulled out of the bout with Mein citing a toe injury. In turn, Mein faced Mike Pyle at the event, as Pyle's scheduled opponent Demian Maia, also pulled out of their bout with a staph infection.

As a result of the cancellation of UFC 176, bouts between Beneil Dariush vs. Tony Martin, James Vick vs. Valmir Lazaro and Matt Dwyer vs. Alex Garcia were rescheduled for this event. However, Dwyer was removed from his bout with Garcia and replaced by Neil Magny.

Ernest Chavez was expected to face Mirsad Bektic at the event. However, Chavez was forced out of the bout with an injury and was replaced by Max Holloway. In turn, Bektic pulled out of the bout in the week leading up to the event and was replaced by promotional newcomer Clay Collard.

Tim Elliott was expected to face Wilson Reis at the event. However, Elliott pulled out of the bout in the days leading up to the event. Reis faced promotional newcomer Joby Sanchez.

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