U7 small nuclear RNA

U7 small nuclear RNA
Predicted secondary structure and sequence conservation of U7
Identifiers
Symbol	U7
Rfam	RF00066
Other data
RNA type	Gene; snRNA
Domain(s)	Eukaryota
SO	0000274

The U7 small nuclear RNA (U7 snRNA) is an RNA molecule and a component of the small nuclear ribonucleoprotein complex (U7 snRNP). The U7 snRNA is required for histone pre-mRNA processing.

The 5' end of the U7 snRNA binds the HDE (Histone Downstream Element), a conserved purine-rich region, located 15 nucleotides downstream the histone mRNA cleavage site. The binding of the HDE region by the U7 snRNA, through complementary base-pairing, is an important step for the future recruitment of cleavage factors during histone pre-mRNA processing.