U.S. Route 65 in Louisiana

U.S. Highway 65
Route of US 65 highlighted in red
Route information
Maintained by Louisiana DOTD
Length:	100.770 mi (162.174 km)
Existed:	1926 – present
Tourist routes:	National Scenic Byways: Great River Road
Major junctions
South end:	US 425 / LA 15 in Clayton
	LA 4 in Newellton I-20 in Tallulah US 80 in Tallulah LA 2 north of Lake Providence
North end:	Arkansas state line north of Gassoway
Location
Parishes:	Concordia, Tensas, Madison, East Carroll
Highway system
United States Numbered Highway System List Special Divided Replaced Louisiana Highway System Interstate US State ← LA 64 LA 66 →

U.S. Highway 65 Bypass
Location:	Baton Rouge
Length:	10.4 mi (16.7 km)
Existed:	1941–1951

U.S. Highway 65 (US 65) is a part of the United States Numbered Highway System that spans 966 miles (1,555 km) from Clayton, Louisiana to Albert Lea, Minnesota. Within the state of Louisiana, the highway travels 100.77 miles (162.17 km) from the national southern terminus at US 425/LA 15 in Clayton to the Arkansas state line north of Lake Providence.

US 65 parallels the west bank of the Mississippi River through the northeastern portion of Louisiana. It traverses four parishes, connecting the parish seats of the northern three. These are Newellton, Tallulah, and Lake Providence, which also constitute the largest towns along the route. In Tallulah, US 65 has a junction with Interstate 20, the principal highway across northern Louisiana. I-20 connects to a bridge across the Mississippi River at Vicksburg, Mississippi, which is the only automobile crossing between Greenville and Natchez.

The Natchez–Vidalia Bridge was part of US 65 prior to 2005 when the designation was replaced by that of US 425 between Clayton and Natchez. During the years 1936 to 1951, US 65 was more than double its present length as it overlapped US 61 from Natchez south to New Orleans.