U.S. Route 340 in Maryland

U.S. Route 340
U.S. Route 340 highlighted in red
Route information
Maintained by MDSHA
Length:	17.01 mi (27.37 km)
Existed:	1926 – present
Tourist routes:	Journey Through Hallowed Ground Byway Chesapeake and Ohio Canal Scenic Byway
Major junctions
West end:	US 340 at Virginia border in Sandy Hook
	MD 67 in Weverton MD 180 in Knoxville MD 17 near Rosemont US 15 near Jefferson I-70 in Frederick
East end:	US 15 / US 40 in Frederick
Location
Counties:	Washington, Frederick
Highway system
United States Numbered Highway System List Special Divided Replaced Maryland highway system Interstate US State Scenic Byways ← MD 338 MD 341 →

MD 67 in Weverton
MD 180 in Knoxville
MD 17 near Rosemont
US 15 near Jefferson

U.S. Route 340 (US 340) is a part of the U.S. Highway System that runs from Greenville, Virginia to Frederick, Maryland. In Maryland, the U.S. highway runs 17.01 miles (27.37 km) from the Virginia state line at the Potomac River at Sandy Hook east to its northern terminus at US 15 and US 40 in Frederick. US 340, which is known for most of its length as Jefferson National Pike, connects Frederick with the communities of Jefferson, Brunswick, and Knoxville in the southern part of the Middletown Valley of western Frederick County and Weverton in far southern Washington County. The U.S. highway also links Frederick with Harpers Ferry and Charles Town in the Eastern Panhandle of West Virginia. US 340 is a part of the National Highway System for its entire length in Maryland.