Tyngsborough (also spelled Tyngsboro) is a town in northern Middlesex County, Massachusetts, United States. Tyngsborough is 28 miles (45 km) from Boston along the Route 3 corridor, and located on the New Hampshire state line. At the 2010 census, the town population was 11,292.

Tyngsborough was settled in 1661, as part of the massive Dunstable Township. The town of Dunstable, incorporated in 1673, was named after the hometown of pioneer Edward Tyng. However, a relative of his, and the source of the town of Tyngsborough's name, was Colonel Jonathan Tyng, whose home, the Tyng Mansion House, was one of the oldest north of Boston. He settled near the Merrimack in what is now Tyngsborough in 1675. The house stood until the 1970s, when it was destroyed by arson. Early on Tyngsborough residents fought a series of small and bloody skirmishes with local Native American tribes. Evidence of this can be found in several old colonial homes in town that still have emergency passages that were used during these attacks. In 1789, Tyngsborough's parish split from the rest of Dunstable, making Tyngsborough a recognized district. On February 23, 1809, Tyngsborough became a town.

After Tyngsborough was incorporated it became known for its ferries which traveled up and down the Merrimack River, the quarries that produced granite, and several box companies that started in town. As the town developed, Tyngsborough became a vacation community and had a large seasonal resident population even up until the late 1960s. A notable summer resident was actress Nance O'Neil, whose estate became the campus of the Academy of Notre Dame.

Today, Tyngsborough primarily serves as a bedroom community, part of Greater Lowell and the Nashua, New Hampshire region, in addition to having a short commute to the Boston area. The town is also known for the Tyngsborough Bridge, a green painted, single-arched, steel bridge over the Merrimack River. Constructed in 1931 as a replacement for an earlier wooden planked structure, this bridge is a major river crossing for residents of Massachusetts and New Hampshire alike with 22,300 daily crossings as of 2007.

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