Two Dozen and One Greyhounds

Frank Welker as Santa's Little Helper and various dogs

"Two Dozen and One Greyhounds" is the 20th episode of The Simpsons' sixth season. It originally aired on the Fox network in the United States on April 9, 1995. The episode was written by Mike Scully and directed by Bob Anderson. Frank Welker guest stars as Santa's Little Helper and various other dogs. In the episode, Santa's Little Helper has puppies with a dog that he met at the greyhound racetrack.

The episode is inspired by Dodie Smith's 1956 novel The Hundred and One Dalmatians and Walt Disney Pictures' 1961 animated film adaptation One Hundred and One Dalmatians. The producers decided to have Mr. Burns communicate his horrific plan of making a tuxedo from the puppies through a song after determining that it would be a "fun and light" way to convey his plan of killing the greyhounds. "Two Dozen and One Greyhounds" received a generally positive reception from television critics. During the week of its original broadcast, the episode finished 55th in ratings, with a Nielsen rating of 7.3. Several reviews considered the episode to be one of their favorites of the series, and especially praised Mr. Burns' appearances.

The Simpson family's dog, Santa's Little Helper, becomes very excited and runs away from home to the dog racing track, where he falls in love with a female greyhound named She's the Fastest. She is given to the Simpsons, and soon gives birth to 25 puppies. Eventually, the puppies become difficult to manage, and Homer and Marge attempt to sell them. After his offer is rejected, Mr. Burns steals the puppies.