Tutin (toxin)

Tutin

Clinical data
ATC code	none
Identifiers
IUPAC name 2a,3a-epoxy- 3a,4a,5,6,7,7a-hexahydro- 3aα,6β,7β-trihydroxy- 5α-isopropyl- 7aα-methylspiro (indan-1,2'-oxirane)- γ-lactone
CAS Number	2571-22-4 Y
PubChem CID	75729
ECHA InfoCard	100.236.780
Chemical and physical data
Formula	C15H18O6
Molar mass	294.299 g/mol

Tutin is a poisonous plant derivative found in the New Zealand tutu plant (Coriaria arborea, Coriaria genus, several different species). It acts as a potent antagonist of the glycine receptor, and has powerful convulsant effects. It is used in scientific research into the glycine receptor, and is also sometimes associated with outbreaks of toxic honey poisoning when bees feed honeydew exudate from the sap-sucking insect commonly known as the passion vine hopper, when these vine hoppers (Scolypopa australis) have been feeding on the sap of tutu bushes. Toxic honey is a rare event and is more likely to occur when comb honey is eaten directly from a hive that has been harvesting honeydew from passion vine hoppers feeding on tutu plants.

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