Trimix is a breathing gas, consisting of oxygen, helium and nitrogen, and is often used in deep commercial diving, during the deep phase of dives carried out using technical diving techniques, and in advanced recreational diving.
The helium is included as a substitute for some of the nitrogen, to reduce the narcotic effect of the breathing gas at depth. With a mixture of three gases it is possible to create mixes suitable for different depths or purposes by adjusting the proportions of each gas. Oxygen content can be optimised for the depth to limit the risk of toxicity, and the inert component balanced between nitrogen (which is cheap but narcotic) and helium (which is not narcotic and reduces work of breathing, but is more expensive and increases heat loss).
The mixture of helium and oxygen with a 0% nitrogen content is generally known as Heliox. This is frequently used as a breathing gas in deep commercial diving operations, where it is often recycled to save the expensive helium component. Analysis of two-component gases is much simpler than three component gases.
The main reason for adding helium to the breathing mix is to reduce the proportions of nitrogen and oxygen below those of air, to allow the gas mix to be breathed safely on deep dives. A lower proportion of nitrogen is required to reduce nitrogen narcosis and other physiological effects of the gas at depth. Helium has very little narcotic effect. A lower proportion of oxygen reduces the risk of oxygen toxicity on deep dives.
The lower density of helium reduces breathing resistance at depth.
Because of its low molecular weight, helium enters and leaves tissues more rapidly than nitrogen as the pressure is increased or reduced (this is called on-gassing and off-gassing). Because of its lower solubility, helium does not load tissues as heavily as nitrogen, but at the same time the tissues can not support as high an amount of helium when super-saturated. In effect, helium is a faster gas to saturate and desaturate, which is a distinct advantage in saturation diving, but less so in bounce diving, where the increased rate of off-gassing is largely counterbalanced by the equivalently increased rate of on-gassing.