Triclosan

Triclosan

Names
Preferred IUPAC name 5-Chloro-2-(2,4-dichlorophenoxy)phenol
Other names 2,4,4'-Trichloro-2'-hydroxydiphenyl ether 5-Chloro-(2,4-dichlorophenoxy)phenol Trichloro-2'-hydroxydiphenyl ether CH-3565 Lexol 300 Irgasan DP 300 Ster-Zac
Identifiers
CAS Number	3380-34-5 Y
3D model (Jmol)	Interactive image
ChEBI	CHEBI:164200 Y
ChEMBL	ChEMBL849 Y
ChemSpider	5363 Y
DrugBank	DB08604 Y
ECHA InfoCard	100.020.167
KEGG	D06226 Y
PubChem	5564
UNII	4NM5039Y5X Y
InChI InChI=1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H Y Key: XEFQLINVKFYRCS-UHFFFAOYSA-N Y InChI=1/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H Key: XEFQLINVKFYRCS-UHFFFAOYAS
SMILES Clc2cc(Cl)ccc2Oc1ccc(Cl)cc1O
Properties
Chemical formula	C12H7Cl3O2
Molar mass	289.54 g·mol−1
Appearance	White solid
Density	1.49 g/cm3
Melting point	55–57 °C (131–135 °F; 328–330 K)
Boiling point	120 °C (248 °F; 393 K)
Pharmacology
ATC code	D08AE04 (WHO) D09AA06 (WHO) (medicated dressing)
Hazards
Safety data sheet	MSDS
NFPA 704	1 2 0
Flash point	162.2 °C (324.0 °F; 435.3 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y  (what is YN ?)
Infobox references

Triclosan, similar in its uses and mechanism of action to triclocarban, is an antibacterial and antifungal agent found in consumer products, including toothpaste, soaps, detergents, toys, and surgical cleaning treatments. Its efficacy as an antimicrobial agent, the risk of antimicrobial resistance, and its possible role in disrupted hormonal development remain controversial. Additional research seeks to understand its potential effects on organisms and environmental health.

Triclosan was developed in the 1960s. In September 2016, the FDA announced that effective September 2017, it would prohibit the sale of "consumer antiseptic washes" containing triclosan or 18 other ingredients marketed as antimicrobials due to FDA findings of the lack of efficacy in these products.

Triclosan was used as a hospital scrub in the 1970s. Since then, it has expanded commercially and is now prevalent in soaps (0.10-1.00%), shampoos, deodorants, toothpastes, mouthwashes, cleaning supplies, and pesticides. It is part of consumer products, including kitchen utensils, toys, bedding, socks, and trash bags.

As of 2012, the technical registrant with the U.S. EPA of triclosan was the antimicrobial technology company Microban. The company website explains that antimicrobial additives are mixed in during a product's manufacturing process and protect its surface throughout its useful life by operating on the cellular level to disrupt and prevent growth of microorganisms. According to the website, the technology is used in appliances, bathroom products, cleaning products, food storage, kitchen products, luggage, office and school products, personal care, pet products, pool and spa linings, sponges, sporting equipment, towels, vacuum cleaners, water filters, and wipes.

By the year 2000, triclosan and triclocarban (TCC) could be found in 75% of liquid soaps and 29% of bar soaps, and as of 2014 triclosan was used in more than 2,000 consumer products.