Transportation in Lancaster County, Pennsylvania has a long and variegated history. An early-settled part of the United States, and lying on the route between Philadelphia and Harrisburg, it has been the site of early experiments in canals, railroads, and highways. Before all these, at least ten Native American paths crossed parts of the county, many connecting with the Susquehannock village of Conestoga.
The principal waterway in Lancaster County is the Susquehanna River, which forms its western border. However, its many rocks and rapids made it difficult for navigation. An attempt was made in 1820 by James Hopkins to dig a canal to bypass the Conewago Falls, already bypassed in 1797 by the Conewago Canal in York County on the opposite side of the river. However, the Hopkins Canal was poorly laid out and not useful for navigation. He was then authorized by the legislature to build a canal along the Conestoga River to Lancaster to connect that city with the Susquehanna, but abandoned it after building one lock.
On March 3, 1825, the Conestoga Navigation Company was incorporated to make a second attempt at improving the Conestoga River. It was placed into operation in 1826. The Conestoga Navigation was 18 miles (29 km) long, with nine locks and dams, between Safe Harbor, at the mouth of the creek, and Lancaster.
Interest in improving the Susquehanna continued. Surveys were made along the east bank from Chickies Rock to the Maryland state line in 1827; the extension of the Eastern Division of the Pennsylvania Canal to Columbia was authorized on March 24, 1828 and again on March 21, 1831, and was completed on December 4, 1832. Revenue service began on April 9, 1833. The construction of the Philadelphia and Columbia Railroad (vide infra) placed Columbia on the route from Philadelphia into the western parts of the state, via the canal. The Susquehanna and Tidewater Canal to Baltimore was ultimately opened in 1840 on the west side of the river, canal boats crossing at Columbia to reach the Pennsylvania Canal.