The Toxaway River is a 21.4-mile-long (34.4 km) waterway that flows south from headwaters in Transylvania County, North Carolina, into Lake Toxaway and over Toxaway Falls, after which it crosses into South Carolina and enters Lake Jocassee, the reservoir behind Lake Jocassee Dam.
In Lake Jocassee the Toxaway River is joined by the Whitewater River to form the Keowee River. The confluence is submerged beneath the waters of Lake Jocassee. Via the Keowee and Seneca rivers, the Toxaway River is part of the Savannah River watershed.
Coordinates: 34°58′36″N 82°56′05″W / 34.9767631°N 82.9345883°W