Tlaltizapán is a city in the Mexican state of Morelos. It stands at 18°4′N 99°07′W / 18.067°N 99.117°W.
The city serves as the municipal seat for the surrounding municipality, with which it shares a name. The municipality reported 45,272 inhabitants in the year 2000 census.
The toponym Tlaltizapán comes from a Nahuatl name and means "on white land".