Tick Creek is a tributary of the Gasconade River in Phelps County in the Ozarks of Missouri.
The stream headwaters are at 37°57′29″N 91°51′09″W / 37.95806°N 91.85250°W and the confluence with the Gasconade is at 38°02′08″N 91°55′24″W / 38.03556°N 91.92333°WCoordinates: 38°02′08″N 91°55′24″W / 38.03556°N 91.92333°W.
Tick Creek most likely was so named on account of ticks in the area.