Sir Thomas Wise (c. 1576 – 1630),KB, of Sydenham in the parish of Marystow and of Mount Wise in the parish of Stoke Damerel in Devon, was Sheriff of Devon in 1612 and in 1621 served as a member of parliament for Bere Alston in Devon.
Wise was the second son and eventual heir of Thomas Wise (1546–1593) of Sydenham, by his wife Mary Buller, a daughter of Richard Buller (died 1556) of Shillingham in Cornwall (ancestor of the prominent Buller family of Morval and of the Buller Baronets). The Wise family is earliest recorded in the Heraldic Visitations of Devon in the person of John Wise (fl.1403) of Sydenham, living in 1403. The family can however be traced to Westcountry roots from the eleventh century. They provided a Knight of the Shire (Member of Parliament for Devon) in three of the Parliaments of King Henry VI (1422–1461). In about 1400 the manor of Stoke Damerel, within which was situated the estate later called Mount Wise, was inherited by Thomas Wise of Sydenham (son and heir of John Wise (fl.1403) of Sydenham), upon his marriage to Margaret Brett (alias Brit), daughter and heiress of Robert Brett of Staddiscombe, near ,lord of the manor of Stoke Damerel.
He was created a Knight of the Bath at the coronation of King James I in 1603. In 1612 he served as Sheriff of Devon. In 1621 he was elected a member of parliament for Bere Alston in Devon, where he had gained influence following local land purchases.