Thomas Sandford (1762 – 10 December 1808) was an American soldier and politician.
He was born in Westmoreland County, Virginia in 1762, son of Youell Sanford (d. 24 January 1794 in Cople Parish, Westmoreland County) and Elizabeth Pope (b. 1732), daughter from a family long important in Virginia politics. In 1770, he inherited 150 acres of land from his paternal grandfather Youell Sanford Sr.
He rose to become a General in the American War of Independence. Following the Revolution, he settled in Kentucky where he had been granted land, in 1792. In his political career he was a state representative and senator, then a representative in the Eighth and Ninth Congresses (1803–1807). He drowned in the Ohio River near Covington, Kentucky on 10 December 1808.
Thomas Sandford was born 1762. He first married Sarah Redman (1768–1805) about 1786 in Westmoreland County, Virginia. They had two sons:
Following the death of his first wife, Thomas Sanford married Margaret Bell (1771–1845). Their son Cassius Bell Sanford (17 June 1808 in Covington - FEB 1871 in Covington) married Francis Susan Leathers (1815 - 27 May 1879). Their sons were Thomas C. Sandford (1836–1864) and John Leathers Sandford (1837–1895), the banker and former CSA colonel who was shot to death by a political rival, William Goebel.