Thomas Peyton (1418–1484) of Isleham, Cambridgeshire, was twice Sheriff of Cambridgeshire and Huntingdonshire, in 1443 and 1453. He rebuilt the church of St Andrew's in Isleham, in the chancel of which survives his monumental brass. He is depicted in a 1485 stained glass window in Long Melford Church, Suffolk, where he displays on his surcoat the Peyton arms: Sable, a cross engrailed or a mullet in the first quarter argent.
His family originated at the manor of Peyton in the parish of Boxford, Suffolk.
Peyton married twice. His first wife was Margaret Bernard, one of the daughters and co-heiresses of Sir John Bernard (died 1451) (whose effigy survives in Isleham Church), lord of the manor of Isleham, through which marriage he inherited that manor. By Margaret Bernard he had children including:
His second marriage was to Margaret Francis, a daughter and co-heiress of Sir Hugh Francis of Giffords in Suffolk, by whom he had further sons:
From him were descended the Peyton baronets of Isleham (1611), the Peyton baronets of Knowlton (1611) and the Peyton baronets of Doddington (1660 and later creations).