Sir Thomas Murfyn (fl. 1510s) was a Sheriff and Lord Mayor of London.
Thomas Murfyn was a native of Ely, in Cambridgeshire, and son of George Murfyn, or Murfine. He was a skinner, or a member of the Skinners' Guild, in London, and served the office of Sheriff of London with Nicholas Shelton, in 1511, and was Lord Mayor in 1518. He probably was not knighted until after his election to the mayoralty.
Sir Thomas married first Elizabeth Squier, by whom he had a son, Edward, who died without issue. He also had a daughter, Frances, who married Richard Williams (alias Cromwell). She died at Stepney and was buried there on 20 February 1533.
Sir Thomas second wife was Elizabeth, only daughter and heiress of Sir Angel Donne, knt. alderman of London, by Anne Hawarden/Hawardine, of Cheshire; one of their daughters, Mary, married another Lord Mayor of London, Andrew Judde. Sir Thomas' last wife survived him and re-married to Sir Thomas Denys/Dennis, knt. by whom she had Sir Robert Denys/Dennis, knt. who by Mary, daughter of William Blount, 4th Baron Mountjoy, had Thomas Denys/Dennis. The arms of the Murfyns were, Or, on a bend sabla' an estoilee arg. those of Dom, Azure, seme of cross-closslets or, an unicorn salient, arg.
Mirfyn is listed as one of the graves lost in the Great Fire of London in 1666, on a monument in the crypt of St Paul's Cathedral, together with several other Lord Mayors.