Thomas Maniatis
| Tom Maniatis | |
|---|---|
| Born |
May 8, 1943 Denver, Colorado |
| Nationality | American |
| Fields | Molecular Biology |
| Institutions | Harvard University, Cold Spring Harbor Laboratory, California Institute of Technology, Columbia University |
| Alma mater | University of Colorado, Vanderbilt University |
| Doctoral advisor | Leonard Lerman |
| Other academic advisors | Mark Ptashne, Fred Sanger |
| Known for | The development and application of gene cloning methods to the study of molecular biology. |
| Notable awards | The Eli Lilly Research Award in Microbiology and Immunology, 1981 Richard Lounsbery Award, 1985 Member, National Academy of Sciences, 1985 Fellow, American Academy of Arts and Sciences, 1985 Pasarow Award in Cancer Research, 2001 Lasker-Koshland Special Achievement Award in Medical Science, 2012 Member, National Academy of Medicine, 2012 |
Tom Maniatis (born May 8, 1943), is an American professor of molecular and cellular biology.
Maniatis is a graduate of the University of Colorado. He received a PhD in Molecular Biology from Vanderbilt University, working with Professor Leonard Lerman. Maniatis has also received Honorary PhDs from the University of Athens, and the Watson School of Cold Spring Harbor Laboratory. Maniatis carried out postdoctoral studies with Professor Mark Ptashne at Harvard University and with Dr. Fred Sanger at the Medical Research Council Laboratory of Molecular Biology in Cambridge, England. Maniatis has held faculty positions at Harvard University, The Cold Spring Harbor Laboratory, the California Institute of Technology, and Columbia University.
As a postdoctoral fellow with Mark Ptashne at Harvard University, Maniatis studied the molecular mechanisms of gene regulation in bacteriophage lambda. He identified multiple bacteriophage lambda repressor binding sites in the operators of the virus, and determined their DNA sequences while working in Fred Sanger's lab at the MRC in Cambridge, England. Maniatis was appointed to the position of assistant professor in the Department of Biochemistry and Molecular Biology in 1975, but carried out his research at Cold Spring Harbor Laboratory because the moratorium on recombinant DNA research in Cambridge, MA prevented his work on cDNA cloning at Harvard. In 1977, Maniatis moved to the California Institute of Technology, where his laboratory generated the first human genomic DNA library, and cloned the human beta-globin gene cluster. In 1981 Maniatis returned to Harvard where he applied molecular cloning methods to the study of the mechanisms of RNA transcription and splicing in eukaryotes. Maniatis moved to Columbia University in 2009 where he serves as the Isidore Edelman Professor of Biochemistry and Molecular Biophysics at the Columbia University College of Physicians and Surgeons in New York. His laboratory currently studies the role of single cell diversity in brain wiring, and the molecular and cellular mechanisms of the neurodegenerative disease Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's disease).
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