Sir Thomas Grenville II (born c. 1453 - died c. 1513), KB, lord of the manors of Bideford in Devon and of Stowe in the parish of Kilkhampton in Cornwall, was Sheriff of Cornwall in 1481 and in 1486. During the Wars of the Roses in his youth he had been a Lancastrian supporter and had taken part in the conspiracy against Richard III organised by the Duke of Buckingham. On the accession of King Henry VII (1485–1509) and the end of the wars, Grenville was appointed one of the Esquires of the Body to Henry VII. On the marriage of Prince Arthur to Katherine of Aragon on 14 November 1501 he was created a Knight of the Bath. He served on the Commission of the Peace for Devon from 1510 to his death.
He was the son and heir of Sir Thomas Grenville I by his second wife Elizabeth Gorges, daughter of Sir Theobald Gorges, K.B., lord of Wraxall, Somerset, and Braunton Gorges, co. Devon. Although little if anything at all survives in historical records concerning his biography, he was the descendant of a notable ancestor who took part in the Norman Conquest of Glamorgan, namely Sir Richard Grenville, one of the Twelve Knights of Glamorgan who won for himself the Welsh lordship of Neath and in 1129 founded there Neath Abbey.
Sir Thomas I was himself ancestor to famous descendants, most notably his great-great-grandson Sir Richard Grenville (1542–1591), the valiant captain of "The Revenge" and of Sir Bevil Grenville (1596–1643), MP and famous Civil War commander, father of John Grenville, 1st Earl of Bath (1628–1701). He was also the ancestor of the Grenville Marquesses of Buckingham, title created in 1784, and the Grenville Dukes of Buckingham and Chandos, a title created in 1822.