Theodora Komnene Kantakouzene (c. 1340 – after 1390) was the Empress consort of Alexios III of Trebizond.
Theodora is considered a daughter of Nikephoros Kantakouzenos, sebastokratōr. According to the history of their kinsman John VI Kantakouzenos, Nikephoros was imprisoned by orders of Alexios Apokaukos, one of the main advisors of Anna of Savoy in the civil war against John VI, in 1341. Nikephoros was later released and recorded as governing Adrianople in the 1350s, having been made sebastokrator. Donald Nicol argues that Nikephoros is a cousin of the Emperor John VI. The identity of Theodora's mother is unknown.
When the deposed Emperor of Trebizond Michael was sent, after a period of incarceration, to Constantinople, he was accompanied by the tatas Michael Sampson, who was tasked to find a suitable wife for the new ruler, Alexios III. Donald Nicol presumes that the Byzantine Emperor John VI directed the search, "for the wife found was his cousin's daughter." She reached Trebizond on 3 September 1351, and on 28 September, she married Alexios. They were married in the newly rebuilt Hagios Eugenios Church. Her new husband was about a week short of his thirteenth birthday; Theodora is considered likely to have been of an equivalent age.
What we know about her life as empress is mostly based on the chronicle of Michael Panaretos, which is always terse. His chronicle mentions Theodora by name six times, including the record of her marriage and death; she is mentioned twice more by only her title of despoina; and for the notices of the births of the two sons of Alexios, her name is omitted. She accompanied Alexios when he marched on John Tzanitches and quashed his revolt in March 1352; she accompanied both Alexios and his mother Irene when he sailed against the rebel megas Doux Niketas Scholares in 1355; she accompanied both again when they fled an outbreak of the Black Death in Trebizond in March 1362; and she attended the wedding of her daughter Anna with both Alexios and his mother in June 1367. Panaretos' only notice of Theodora which can not be explained as part of her role as wife or Empress is her surprising participation in the funeral procession for the illegitimate son of Alexios, Andronikos, along with her rival, his mother; Andronikos had died under suspicious circumstances after falling from the citadel 14 March 1376.