Theiler's encephalomyelitis virus

Theiler's Murine Encephalomyelitis Virus
Virus classification
Group:	Group IV ((+)ssRNA)
Order:	Picornavirales
Family:	Picornaviridae
Genus:	Cardiovirus
Species:	Cardiovirus B
Isolate
Theiler's Murine Encephalomyelitis Virus

Theiler's Murine Encephalomyelitis Virus

Theiler's Murine Encephalomyelitis Virus (TMEV) is a single-stranded RNA murine cardiovirus from the family Picornaviridae. It has been used as a mouse model for studying virally induced paralysis, as well as encephalomyelitis comparable to Multiple sclerosis. Depending on the mouse and viral strain, viral pathogenesis can range from negligible, to chronic or acute encephalomyelitis.

The virus was discovered by virologist Max Theiler in 1937 while working at the Rockefeller Institute. Theiler discovered the encephalomyelitis virus during research on poliovirus-like paralysis symptoms in mice. That year Theiler had completed work on developing a vaccine for Yellow Fever, for which he is best known; in 1951 he received the Nobel Prize for that achievement.

The several different strains of TMEV are characterized by their pathology as well as genetic sequencing and proteomics. The two major groups are listed below, but there are several other strains in the same group as DA (such as BeAn).

TMEV GDVII virus is characterized by acute encephalomyelitis in susceptible mice, with a high mortality rate and no viral persistence after viral clearance by the immune system. No demyelination occurs in surviving mice. The GDVII L protein is specific in that it down-regulates the anti-viral response by inhibition of Interferon Regulatory Factor 3 (IRF3) after it is activated by hyperphosphorylation, but before it is able to enhance Interferon-β transcription by binding to the gene's promoter.

...
Wikipedia