"The Perfect Drug" is a song by Nine Inch Nails. It was written for the David Lynch film Lost Highway and originally appeared on the Lost Highway soundtrack and as a single from the score in 1997. Remixes of the song were released in an EP, "The Perfect Drug" Versions.

Though "The Perfect Drug" Versions acts as a single for the titular song, the original version does not appear on the American single. A slightly extended version of "The Perfect Drug" has also been included on the foreign singles "We're in This Together, Part 3" and "Into the Void", but the only audio release of it in North America has been on the Lost Highway soundtrack. The music video for song was directed by Mark Romanek, and is on the Closure video compilation and The Work of Director Mark Romanek.

Despite being a single, "The Perfect Drug" has never been performed live. On the official NIN website, "Sara" asked whether this is because "the drum solo would make Jerome's arms fall off." Then-drummer Jerome Dillon replied that they "never rule out the possibility of playing any of the songs live."

On April 6, 2005, despite the song's fast-moving worldwide success, while presenting the late-night BBC Radio 1 Rock Show in the UK, Trent Reznor responded to the question "which piece of your own work are you least satisfied with and why?" by saying "the only thing I think I really don't like that much is "The Perfect Drug" song. It was one of those things where you have a week to do a track for a movie, the mindset that you kind of adapt in that situation, or I did, was 'let's go in and experiment and see what happens, and it's not, y'know, whatever comes out of it, it's not the end of the world'. And I think what came out of it, married with a bloated, over-budget video, feels like ... the least thing that I would play to somebody if they said play me, y'know, the top hundred songs you've written, that probably wouldn't be in the top hundred. I'm not cringing about it, but it's not my favorite piece."

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