The music video for "The Denial Twist" was directed by Michel Gondry. Like some of his previous work (namely The Chemical Brothers' "Let Forever Be" and Kylie Minogue's "Come Into My World"), the video features a spectacular array of visual effects as it follows The White Stripes from a talk show performance to a late night drive back to an apartment. As the camera pans in a circle, Jack and Meg appear distorted. This refers to the lyric of the song; that what people think is true is often shaped by the context in which information is presented to them and their willingness to be deceived—even by themselves—as various aspects of the video radically shift in perspective, size, proportion and believability. The choice of Late Night with Conan O'Brien as a setting for the video, aside from the band's personal association, is due to the lesser known fact that, like many film and TV sets, the Late Night stage looks much larger on television than it actually is.

The optical illusion used in the video is the technique of forced perspective, through an Ames room and distortions derived from it.

The creators of the distorted props, Jeff Everett and John Furgason, won a Music Video Production Association Award for Art Direction in 2006.

Conan O'Brien makes a cameo appearance in the video; The White Stripes had been a week-long musical guest on Late Night with Conan O'Brien when they were promoting Elephant. The square-headed O'Brien doll in the video was a reference to a similar one given to the comedian at the end of their week-long stay on the show. The plaster blow-up was actually created by Gondry.

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