"That's What Little Girls Are Made Of" is the debut mainstream single from Raven-Symoné featuring rapper Missy Elliott (credited as her full name "Melissa Elliott"), taken from her debut studio album, Here's to New Dreams. This is Symoné's highest chart appearance to date.

The song was written and produced by Missy Elliott, who performs a verse of scat singing and Jamaican-style toasting, but the music video featured a thinner light-skinned actress lip-syncing her part. On Behind the Music Elliott reveals that she was not informed of the video shoot and later told she "didn't quite fit the image that we were looking for" — later taking her revenge with an oversized garbage-bag costume in her groundbreaking 1997 video "The Rain (Supa Dupa Fly)."

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