"Take It to the Head" is a song by American hip hop producer DJ Khaled, released as the lead single from his sixth studio album, Kiss the Ring. The song features American singer Chris Brown and rappers Rick Ross, Nicki Minaj and Lil Wayne. The song was premiered via DJ Khaled's Twitter on March 26, 2012. It was later released for digital download in the United States on April 3, 2012. The single has sold over 500,000 copies and certified Gold by the RIAA.

David Jeffries highlighted it and wrote a positive description: " Nicki Minaj joins labelmate Wayne, along with Chris Brown and Rick Ross, for "Take It to the Head," a song perfect for rainy days as the lyricists go from sullen to champion over a slow-rolling Runners production." BBC music said of the single, "Single Take It to the Head, meanwhile, is oddly ineffectual considering the talent showcased. Rick Ross comes off lackadaisical, Nicki Minaj offers far from her greatest verse, a mumbling Lil Wayne's mouth sounds fuller of iced grill than usual, while Khaled hollers unselfconsciously over the whole palaver like an actual ghetto Tim Westwood." Mark Bozzer also wrote a positive review: "the Runners/Khaled-produced bachelorette party favourite, "Take It To The Head," featuring Breezy, Rozay, Nicki Minaj and Weezy." XXL panned the song noting it incapable of recapturing the magic of last album’s lead single but he also wrote that it's better than today’s average radio record: "appreciate in listening value over time."

The video was filmed on April 30, 2012 in Universal Studios California. It was directed by Colin Tilley. It premiered on May 20, 2012 on MTV2 Sucker Free and it was uploaded on DJ Khaled's Vevo account on May 25. In addition to Khaled and the track's featured artists, the video features cameos from rappers Drake, Birdman, Busta Rhymes and Mack Maine, among others. The video takes place at The BART. Brown appears in a cage as he sings the chorus. Rick Ross performs his verse on the sidelines of the train tracks as during the verse, Drake appears. Then Minaj raps her verse sitting on the train tracks as gasoline barrels on fire behind her. Then Wayne performs on the back of a destroyed train as Busta Rhymes, Mack Maine and Birdman make small appearances during Wayne's verse.

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