Takatsukasa Nobufusa (鷹司 信房?, 1565 – 1657) was a court noble (kuge) of the early Edo period. Born to Nijo Haruyoshi and adopted by Takatsukasa Tadafuyu he revived the lineage of the Takatsukasa family. In 1606 he was appointed Kampaku, a regent position which he left two years later. In 1657 he died at age 93. With a daughter of the daimyo Sassa Narimasa, he had a son, Nobuhisa, and a daughter, Takako, who married Tokugawa Iemitsu at 1623.