The Takasu Domain (高須藩 Takasu-han?) was a Japanese domain located in Mino Province (present-day Kaizu, Gifu). For most of its history, it was ruled by the Takasu-Matsudaira, a branch of the Tokugawa clan of Owari.
Matsudaira Katamori, Matsudaira Sadaaki, Tokugawa Yoshikatsu, and Tokugawa Mochinaga, four important figures in Bakumatsu-era Japan, were the sons of Matsudaira Yoshitatsu, one of Takasu's last daimyo.
The domain was disestablished in 1870 and its holdings re-merged with those of the Owari Domain, from which it had initially been created.
Coordinates: 35°13′25″N 136°37′54″E / 35.223683°N 136.631528°E