The Sybil Brand Institute was a county jail in Los Angeles County, California, for female inmates. It is named for Sybil Brand.
The jail was completed in 1963 and at one time had over 2,000 inmates. It was closed in 1997 because of its poor physical condition as a result of damage suffered during the 1994 Northridge earthquake.
Since 1997, the jail has been used in movies and television shows such as 24, Reno 911!: Miami, CSI, Legally Blonde, and Desperate Housewives.